| Индекс УДК | 615.281.015.45:616.155.3 |
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Investigation of the effect of a new 1,3-diazinon-4 derivative during its long-term administration on leukopoiesis in rats Electronic resource |
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| Аннотация | Diseases, such as leprosy and tuberculosis, require the long-term administration of antibacterial drugs. Dapsone is the primary drug for their treatment. However, it has a serious side effect on blood. A synthesized drug, a diazinon derivative, showed a high antimycobacterial activity and no toxic effect on blood counts in the experiment. Objective: to investigate the effect of PYATd1 versus Dapsone on leukopoiesis in rats. Materials and methods. An experiment was carried out in 60 Wistar rats of both sexes. Blood taken from the sublingual vein was stabilized with heparin. White blood cell counts were measured with a Mindray BC 2800vetaanalysis system used in veterinary hematology. Results. The long-term use of new 1,3-diazinon-4 derivative versus Dapsone was examined for its impact on white blood cell counts in the rats. The effects of the drugs on the counts of segmented neutrophils and eosinophils, young stab neutrophils and nuclear shift index were considered. Conclusion. No statistically significant changes in the complete blood count of the animals were observed during 90-day administration of the test compound, suggesting that it had no destructive effect on leukopoiesis in the rats. |
| Ключевые слова | dapsone |
| Название источника | Фармация |
| Место и дата издания | 2016 |
| Прочая информация | V. 65, № 6. - Р. 52-55 |
| Имя макрообъекта | Voronkov_investigation |
