| Маркер записи | n 22 3 4500 |
| Контрольный номер | uchm20_to89_no9_ss879_ad1 |
| Дата корректировки | 14:43:59 23 декабря 2020 г. |
| Кодируемые данные | 201202s2020||||RU|||||||||||#||||# rus0| |
| Системный контрольный номер | RUMARS-uchm20_to89_no9_ss879_ad1 |
| AR-MARS | |
| Служба первич. каталог. |
Научная библиотека Чувашского государственного университета МАРС |
| Код языка каталог. | rus |
| Код языка издания |
eng eng |
| Индекс УДК | 544 |
| Индекс ББК |
24.5 24.5 |
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Таблицы для массовых библиотек Таблицы для массовых библиотек |
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Zlatopolskiy, B. D. PhD; Senior scientist Institute of Neuroscience and Medicine at the Forschungszentrum Julich GmbH; Institute of Radiochemistry and Experimental Molecular Imaging at the University Clinic of Cologne 070 |
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{11}C- and {18}F-labelled tryptophans as PET-tracers for imaging of altered tryptophan metabolism in age-associated disorders B. D. Zlatopolskiy, H. Endepols, R. N. Krasikova [et al.] |
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| Иллюстрации/ тип воспроизводства | 18 рис. |
| Текст | |
| непосредственный | |
| Библиография | Библиогр.: с. 893-896 (159 назв. ) |
| Аннотация | The ageing of the world's population is the result of increased life expectancy observed in almost all countries throughout the world. Consequently, a rising tide of ageing-associated disorders, like cancer and neurodegenerative diseases, represents one of the main global challenges of the 21st century. The ability of mankind to overcome these challenges is directly dependent on the capability to develop novel methods for therapy and diagnosis of age-associated diseases. One hallmark of age-related pathologies is an altered tryptophan metabolism. Numerous pathological processes including neurodegenerative and neurological diseases like epilepsy, Parkinson's and Alzheimer's diseases, cancer and diabetes exhibit marked changes in tryptophan metabolism. Visualization of key processes of tryptophan metabolic pathways, especially using positron emission tomography (PET) and related hybrid methods like PET/CT and PET/MRI, can be exploited to early detect the aforementioned disorders with considerable accuracy, allowing appropriate and timely treatment of patients. Here we review the published {11}C- and {18}F-labelled tryptophans with respect to the production and also preclinical and clinical evaluation as PET-tracers for visualization of different branches of tryptophan metabolism. |
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Химия AR-MARS Физическая химия в целом AR-MARS |
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| Ключевые слова |
возрастные заболевания метаболизм триптофана позитронно-эмиссионная томография триптофаны |
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Endepols, H. PhD; Professor Institute of Radiochemistry and Experimental Molecular Imaging and the Department of Nuclear Medicine at the University Hospital Cologne 070 Krasikova, R. N. PhD Radiochemistry laboratory of N. P. Bechtereva Institute of Human Brain Russian Academy of Science 070 Fedorova, O. S. PhD; Senior scientist Radiochemistry laboratory of N. P. Bechtereva Institute of Human Brain Russian Academy of Science 070 Ermert, J. PhD; Professor Institute of Neuroscience and Medicine at the Forschungszentrum Julich GmbH 070 Neumaier, B. PhD; Professor Institute of Radiochemistry and Experimental Molecular Imaging at the University Clinic Cologne; Institute of Neuroscience and Medicine at the Forschungszentrum Julich GmbH 070 |
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| ISSN | 0042-1308 |
| Название источника | Успехи химии |
| Место и дата издания | 2020 |
| Прочая информация | Т. 89, № 9. - С. 879-896 |
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RU 42813093 20201202 RCR |
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RU 42813093 20201202 |
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RU AR-MARS 20201202 RCR |
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RU AR-MARS 20201202 |
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| Тип документа | b |
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code year to no ss ad |
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uchm 2020 89 9 879 1 |
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| 244 |
